Chemistry

Biography

Biography: Temur Kantaria

Abstract

The elaboration of nano- and microscale drug delivery systems is a topical issue today since the selective (targeted) drug delivery is one of the basic problems of modern drug therapy. The important technological advantages of polymeric NPs usage as drug carriers are their high stability, high carrier capacity, feasibility of encapsulation of both hydrophilic or hydrophobic substances, as well as a high variety of possible administration routes. One of the most promising for the design of NPs are α-amino acid-based biodegradable polymers, called as “pseudo-proteins”, because they can be cleared from the body after the fulfilment of their function. One of the most promising representatives of the pseudo-proteins are poly(ester amide)s (PEAs) composed of non-toxic building blocks like fatty diols and dicarboxylic acids along with α-amino acids. In our previous study, we have reported a systematic study for the preparation of biodegradable NPs by nanoprecipitation method using PEAs. The present work deals with the fabrication of the surface modified biodegradable NPs that includes the PEGylation (coating NPs with polyethylene glycol cloud) and imparting positive charge to NP’s. The PEGylation of NPs is important for improving their stability against immune system, whereas positive surface charge is important for enhancing permeability through the biological barriers. The PEA 8L6 composed of L-leucine (L), 1,6-hexanediol (6) and sebacic acid (8) was used as a basic polymer for fabricating the NPs. An originally designed comb-like co-PEA, containing lateral PEG-2000 chains along with 8L6 anchoring fragments (8L6-PEG), was used as a PEGylating surfactant.