10^th International Conference on Chemistry May 09-10, 2019 Amsterdam, Netherlands

Chair

Apichat Boontawan

Suranaree University of Technology, Thailand

Session Introduction

Imeda Rubashvili

Ivane Javakhishvili Tbilisi State University, Georgia

Title: Wastewater treatment of antibiotics using natural zeolite

Biography:

Imeda Rubashvili has completed his PhD from Georgian Technical University and Post-doctoral study from the University of Liege. He is a Senior Scientific Researcher at Petre Melikishvili Institute of Physical and Organic Chemistry of Ivane Javakhishvili Tbilisi State University and the Head of Validation Department of a pharmaceutical company Aversi-Rational Ltd. He has published more than 30 scientific papers in reputed peer-reviewed journals. He is the Member of the Council of Young Scientists of the Georgian National Academy of Sciences.

Abstract:

Pollution of aquatic ecosystems is a threat not only to the aquatic environment, but also to the vital activity of humans and all living organisms. A special place in this series is occupied by pharmaceuticals. Dehydrated zeolite is a microcrystalline “sponge” in which the pore volume is up to 50% of the volume of the zeolite framework. Such a structure, having an entrance window diameter of 0.3 to 1.0 nm (depending on the type of zeolite), is a highly active adsorbent. In the present work, the adsorption properties of the natural and modified forms of the clinoptilolite zeolite from the Georgian Handaky deposit with respect to some fluoroquinolones, as well as cephalosporins were investigated. The study of the adsorption process was carried out in dynamic conditions. Basic information about the operation of the zeolite sorbent layer was obtained by constructing output curves in the coordinates C/Co - τ, where C is the concentration of the components of pollutants, τ is time. The experiments were carried out before the complete development of the zeolite layer. From the graphic data were calculated: dynamic (ad) and equilibrium (aeq.) activity; the time of the protective action of the sorbent layer (τ); the length of the mass transfer zone (Lo) and the degree of use of the sorbent layer (η). Each control antibiotic was determined quantitatively in test solutions using the HPLC method validated with respect to system suitability test, specificity, linearity-range, accuracy limit of detection (LOD) and quantitation (LOQ). Hence, this study demonstrated and proved that natural zeolite could be an effective adsorbent for removal of the selected antibiotics from wastewaters.

Elisheva Sasson

Bar Ilan University, Israel

Title: Engineering of new proteinoids and proteinoid nanoparticles of narrow size distribution for anti-fog applications

Biography:

Elisheva Sasson is ​​a PhD Candidate from the Institute of Nanotechnology and Advanced Materials in the Department of Chemistry at the Bar-Ilan University. Her research deals with the Design of Coatings on Plastic Films by Proteinoisd and Proteinoid Nanoparticles for Anti-Fog Applications. This work is carried out under the supervision of Professor Shlomo Margel.​

Abstract:

The “fog phenomenon” describes the formation of tiny droplets of water on different surfaces. In day-to-day life, fog affects the light transmission and damages the visibility of different surfaces, such as plastic packaging, lenses, mirrors and windshields. In this study, a new thin coating onto polypropylene films, made of proteinoids and proteinoid nanoparticles for fog prevention presented. The proteinoids and proteinoid nanoparticles were synthesize by thermal step-growth polymerization of amino acids and therefore are non-toxic, and biodegradable and biocompatible. The anti-fogging ability of proteinoids and proteinoid nanoparticles was discussed in terms of wettability, surface chemistry and morphology, which were measured by contact angle and atomic force microscopy. The efficiency of the anti-fog coatings was also tested by hot and cold fog tests to examine the optical properties of the films under fog formation conditions. The obtained results revealed that the proteinoids and proteinoid nanoparticle coatings perform as a wetting enhancer, mainly due to the low water contact angle (7-40°), that can be attributed to the hydrophilic residues of the proteinoid. Furthermore, proteinoids and proteinoid nanoparticles improved the film roughness by smoothing the surface of films (0.7-1.5 nm). In fog tests, uncoated PP film display many small water drops on the surface that damaged the transparency of the film. In contrast, PP films coated with proteinoids or proteinoid nanoparticles formed a clear continuous thin layer of water on the surface. Additionally, the coating did not affect the clarity and haze of the films. Therefore, the coated films may be utilized in many applications, such as food packaging, agriculture and esthetic nylon wraps.

Hanna P. Steinmetz

Bar Ilan University, Israel

Title: Graft polymerization of styryl bisphosphonate monomer onto polypropylene fi lms for inhibition of biofi lm formation

Biography:

Hanna P Steinmetz is ​​a PhD Candidate from The Institute of Nanotechnology and Advanced Materials in the Department of Chemistry at the Bar-Ilan University. Her research focuses on the Design of Bisphosphonate Coating and Polymeric Bisphosphonate Nanoparticles Grafted onto Polymeric Films for Biomedical Applications. This work is carried out under the supervision of Professor Shlomo Margel.​

Abstract:

There has been increased concern during the past few decades over the role bacterial biofilms play in causing a variety of health problems, especially since they exhibit a high degree of resistance to antibiotics and are able to survive in hostile environments. Biofilms consist of bacterial aggregates enveloped by a self-produced matrix attached to the surface. Ca²⁺ ions promote the formation of biofilms, and enhance their stability, viscosity, and strength. Bisphosphonates exhibit a high affinity for Ca²⁺ ions, and may inhibit the formation of biofilms by acting as sequestering agents for Ca²⁺ ions. Although the antibacterial activity of bisphosphonates is well known, research into their anti-biofilm behavior is still in its early stages. In this study, we describe the synthesis of a new thin coating composed of poly (styryl bisphosphonate) grafted onto oxidized polypropylene films for anti-biofilm applications. This grafting process was performed by graft polymerization of styryl bisphosphonate vinylic monomer onto O₂ plasma-treated polypropylene films. The surface modification of the polypropylene films was confirmed using surface measurements, including X-ray photoelectron spectroscopy, atomic force microscopy, and water contact angle goniometry. Significant inhibition of biofilm formation was achieved for both Gram-negative and Gram-positive bacteria.

Shiao-Wei Kuo

National Sun Yat-Sen University, Taiwan

Title: New thermosetting resin based on benzoxazine chemistry

Biography:

Shiao-Wei Kuo is Professor in the Department of Materials and Optoelectronic Science at National Sun Yat-Sen University, Taiwan. He received his PhD in Applied Chemistry from National Chiao-Tung University, Taiwan. After some years of postdoctoral research work there and in the University of Akron, USA, he joined National Sun Yat-Sen University as a faculty member. Now, he is also the Coordinator of Polymer Science and Engineering Program, Ministry of Science and Technology in Taiwan , RSC Fellow, associate editor in Journal of Polymer Reserach, and several editorial borad members in journals. His research interests include polymers, supramolecules, self-assembly nanostructures, mesoporous materials, POSS nanocomposites, low surface free energy materials, and polypeptides. He has published over 300 SCI papers and several book and book chapters. His total ciatition is > 10000 and H-index is 53.

Abstract:

The organic/inorganic hybrid materials from polybenzoxazine (PBZ) have received much interesting recently due to their excellent thermal and mechanical properties, flame retardance, low dielectric constant, well-defined inorganic framework at nanosized scale level, and higher performance relative to those of non-hybrid PBZs. This talk will describe the synthesis, dielectric constants, and thermal, rheological, and mechanical properties of covalently bonded mono- and multifunctionalized benzoxazine hybrids, other functionalized benzoxazine derivatives, and non-covalently (hydrogen) bonded benzoxazine composites.

Session Introduction

Marine Zautashvili

Ivane Javakhishvili Tbilisi State University, Georgia

Title: Development and validation hplc methods for determination of some antibiotics in support of their adsorption study on natural zeolite

Biography:

Marine Zautashvili has completed her PhD from Petre Melikishvili Institute of Physical and Organic Chemistry, in 2012. She is a Senior Scientific Researcher and the Member of the Academic Council of Ivane Javakhishvili Tbilisi State University. She has published more than 60 scientific papers in peer-reviewed journals.

Abstract:

Residual antibiotics pollution has become one of the most serious environmental and human health problems today. Therefore, it has been a great exigency to develop some efficient and cost-effective treatment methods and technologies for antibiotics removal from industrial and household contaminated water. There is the most used technique - adsorption for treatment of wastewaters. Due to high cation-exchange ability as well as to the molecular sieve properties, natural zeolites have been widely used as adsorbents for removal of the frequently used some antibiotics from wastewaters and in purification process. The present research concerns the development and validation for quantitative determination HPLC methods of three antibiotics, from fluoroquinolones drug class – moxifloxacin and norfloxacin and from cephalosporin drug – ceftriaxone in support of adsorption properties study on the selected natural zeolite and modified forms in aqueous solutions. The HPLC methods were developed and validated with respect to system suitability test, specificity, linearity-range, accuracy, precision, limit of detection (LOD) and quantitation (LOQ) according to ICH guideline. The stability of solutions and filter compatibility were checked as well. The calibration curves of developed HPLC methods are linear over a concentration range from 0.1 µg/mL (LOQ) to 200 µg/mL for ceftriaxone, from 0.05 µg/mL (LOQ) to 100 µg/mL for moxifloxacin and norfloxacin; the average recovery is not less than 98.0% for each analytes.

Mylène Campredon

Aix-Marseille Université, France

Title: Rapid characterization of cocaine in illicit drug samples by 1D and 2D NMR spectroscopy

Biography:

Mylène Campredon has completed her PhD in Chemistry from the University of Provence (1986), Marseille France. She has spent two years as a Post-doctoral Research Associate in Ottawa, Canada (1987-1988) working at the National Research Council. She is Professor in Chemistry at Aix-Marseille University and is actively involved in academic, departmental, university and research activities. She has published more than 35 papers in international journals and has been serving as a Referee Member for C. R. Chim., Dyes and Pigments, and Flavor and fragrance Journal. Her current research interest includes the development and application of novel methods in liquids NMR spectroscopy.

Abstract:

The most commonly used techniques for the identification of forensic drug samples are HPLC and GC/MS because they can provide specific spectral data on individual compounds in a complex mixture without prior isolation. Recently, Diffusion Ordered SpectroscopY (DOSY) has been increasingly applied to the analysis of mixtures of small organic molecules. The usefulness of DOSY NMR has been demonstrated in the analysis of heroin in solution. In parallel, alternative NMR approaches suited for mixture analysis have been sought and developed. Among those, ¹H Maximum-Quantum NMR has provided the highest resolution, up to tens of molecules in favourable cases. We here report a simple and fast method to detect the presence of cocaine in illicit drug samples by nuclear magnetic resonance (NMR) spectroscopy. This is achieved by combining the commonly used 1D spectra and diffusion-ordered spectroscopy and introducing the 2D maximum-quantum NMR approach to forensic analysis. By relying on non-uniform sampling acceleration of 2D spectroscopy, the identification can be obtained in less than 3 min for 10 mg of product. Moreover, we will show that the intermolecular interactions of the sample constituents, while affecting the analysis result, do not interfere with the quality of the detection of the proposed protocol.

Temur Kantaria

Kakha Bendukidze University Campus, Georgia

Title: Elaboration of biodegradable PEGylated nanoparticles made of α-amino acid based "pseudo-proteins"

Biography:

Temur Kantaria is currently a Post-doctoral Researcher at Agricultural University of Georgia. He obtained his PhD in Chemistry from Agricultural University of Georgia and Free University of Tbilisi in 2018. He has published five scientific papers and 25 conference papers. He has his expertise in the preparation and characterization of nanoparticles on the basis of amino acid based biodegradable poly(ester urea)s (MS thesis, 2015, Georgian Technical University); and in the preparation, surface modification and characterization of new biodegradable nano- and microparticles on the basis of pseudo-proteins - poly(ester amide)s and poly(ester urea)s (PhD thesis, 2018).

Abstract:

The elaboration of nano- and microscale drug delivery systems is a topical issue today since the selective (targeted) drug delivery is one of the basic problems of modern drug therapy. The important technological advantages of polymeric NPs usage as drug carriers are their high stability, high carrier capacity, feasibility of encapsulation of both hydrophilic or hydrophobic substances, as well as a high variety of possible administration routes. One of the most promising for the design of NPs are α-amino acid-based biodegradable polymers, called as “pseudo-proteins”, because they can be cleared from the body after the fulfilment of their function. One of the most promising representatives of the pseudo-proteins are poly(ester amide)s (PEAs) composed of non-toxic building blocks like fatty diols and dicarboxylic acids along with α-amino acids. In our previous study, we have reported a systematic study for the preparation of biodegradable NPs by nanoprecipitation method using PEAs. The present work deals with the fabrication of the surface modified biodegradable NPs that includes the PEGylation (coating NPs with polyethylene glycol cloud) and imparting positive charge to NP’s. The PEGylation of NPs is important for improving their stability against immune system, whereas positive surface charge is important for enhancing permeability through the biological barriers. The PEA 8L6 composed of L-leucine (L), 1,6-hexanediol (6) and sebacic acid (8) was used as a basic polymer for fabricating the NPs. An originally designed comb-like co-PEA, containing lateral PEG-2000 chains along with 8L6 anchoring fragments (8L6-PEG), was used as a PEGylating surfactant.