11^th International Conference on Chemistry July 20-21, 2020 Florence, Italy

Biography:

Salem E. Zayed Is a Lecturer at University of South Valley and his research field includes the Synthesis of some new sulfur content compounds ( in the form of thiols,thiones, hetrocyclic sulfur and/or combined with other elements), andstudy the biological activities. e. g. Anticancer, Tuberculoses, and anti-infecte micro-organisms like Bacteria, Fungi.

 

 

 

 

Abstract:

Acid catalyzed reaction of 1-(1H-indol-3-yl)-3,3-dimercaptoprop-2-en-1-one (1) with anthranilic acid (2) was achieved to produce 2-(1H-indol-3-yl)-4-oxo-1,4-dihydroquinoline-3-carbodithioic acid (3). Reactions of (1) with some amines e.g. p-chloroaniline (4) and o-aminophenol (5) in equimolar ratios and different reaction conditions were explored to produce (E)-3-((4-chlorophenyl)imino)-3-(1H-indol-3-yl)prop-1-ene-1,1-dithiol (6) and (E)-2-(benzo[d]oxazol-2(3H)-ylidene)-1-(1H-indol-3-yl)ethan-1-one  (7) respectively. While reaction of (1) with 3,5- dibromosalicyldehyde (8) or glucose (9), (6,8-dibromo-4-hydroxy-2-mercaptochroman-3-yl)(1H-indol-3-yl)methanone  (10) and 2-(dimercaptomethylene)-3,4,5,6,7,8-hexahydroxy-1-(1H-indol-3-yl)octan-1-one  (11) were obtained respectively. Also 5-(1H-indol-3-yl)-3H-1,2-dithiole-3-thione (12) was obtained from the reaction of (1) with P₂S₅. On treatment (12) with different reagents as 3,5-dibromosalicyldehyde (8) and anthranilic acid (2) gave the adducts  6,8-dibromo-3-(1H-indol-3-yl)-9a-mercapto-3H,9aH-[1,2]dithiolo[3,4-b]chromen-4-ol (13) and 3-(1H-indol-3-yl)-9a-mercapto-9,9a-dihydro-4H-[1,2]dithiolo[3,4-b]quinolin-4-one (14) respectively

Biography:

Vijay Kumar Sharma is pursuing  his PhD from Amity University Uttar Pradesh, Sector-125, Noida, India. He has done M.Sc. in Pharmaceutical Chemistry from Guru Nanak Dev University Amrtisar, India in 2007. He is working as Senior Research Scientist in Integral Bio Sciences Pvt. Ltd, Noida, Indiap-a drug discover incubator. He has worked as synthetic chemist for  project in drug discovery for various collaborators and involved in synthesis of novel scaffolds on mg to gram scale. He has a experience of over 12 years in this area and  worked with premier organization such as Ranbaxy Laboratories, Gurugram, India. (now Sun Pharmaceutical Industries Limited) and Jubilant Chemsys Limited Noida, India

 

 

Abstract:

Quinazolines are pivotal heterocycles in medicinal chemistry. These have been isolated from different plants and microorganisms and are often the central core of complex natural products such as farinamycin [1], phaitanthrin C and methylisatoid [2] etc. (Figure 1) which have various biological Further, many synthetic quinazoline derivatives such as batracyclin for its anti-tumor activity [5], and the piperazine-containing trimazosin and prazosin for the treatment of high blood pressure, symptoms of an enlarged prostate, post-traumatic stress disorder (PTSD) and preventing neurodegenerative diseases such as Parkinson’s disease (PD All of these derivatives have been synthesized by multistep reactions with low to moderate yields.We have reported  an efficient and eco-friendly method for a one-pot sequential synthesis of quinazolin-8-ol derivatives. A variety of boronic acids were used for Suzuki-Miyaura coupling with commercially-available SiliaCat®DPP-Pd heterogeneous catalyst. Use of this catalyst ensures minimal leaching of palladium in the product and alleviates the need of further purification.  The reaction conditions used in the four synthetic steps were optimized to telescope three intermediates without first requiring their isolation to establish an efficient and eco-friendly one-pot synthesis Significance, synthetic strategy, experimental details and characterization of these newly developed interesting molecules

Biography:

Tao WANG received his Master`s degree in “Medicinal Chemistry” from the University of Guizhou in 2012. In 2013, he worked as a lecturer at the School of Pharmaceutical Engineering of Guizhou Institute of Technology. In 2016, he started his PhD titled “Novel Multivalent Molecules as Antibiofilm and Antibacterial Agents” at the University of Namur under the supervision of Professor Stéphane VINCENT  in the research unit of Organic and Bio-organic Supramolecular Chemistry.

 

Abstract:

The accelerated drug resistance of bacteria is one of the most serious problems in global healthcare and the difficulties in finding new antibiotic drugs are even more challenging. Almost 80% of bacterial infections of living tissues are associated with bacterial biofilms, including lung infections of cystic fibrosis patients, colitis, urethritis, conjunctivitis, otitis, endocarditis and periodontitis.[1] Multivalency is ubiquitous in biological interactions, especially in carbohydrate-mediated processes. The low affinity of carbohydrate-mediated interactions is compensated by clustering of the ligands.[2,3] However, in real biological systems, the interfaces are usually not flat, which exhibit distinct size-features from microns (e.g., cell membranes) or sub-micron (e.g., organelles or vesicles) to several nanometers (e.g., proteins, micelles). theoretical investigation indicated the size may have great influence on folding of proteins adsorbed on nanoparticles.[4] At the same time, gold nanoparticles have interesting characteristics including a three-dimensional (3D) polyvalent carbohydrate network, a globular shape and a chemically well-defined composition.

In this project, we have designed novel multivalent gold nanoparticles with functionalized fullerene-C60, to investigate size-effect of inhibition of bacterial biofilms by the gold nanoparticle conjugates

Biography:

Kyung-Hoon Lee is a PHD Graduate from the University of Chauhan and presently working as an Assistant Professor in Department of Biology at Chowan University.

 

Abstract:

Islet amyloid polypeptide (IAPP, also known as amylin) is a 37 residue neuropancreatic polypeptide hormone, which helps to regulate satiety, control gastric emptying, suppress glucagon release and maintain glucose homeostasis by suppressing insulin-mediated glucose uptake.  IAPP forms amyloid in the islets of Langerhans in type-2 diabetes, a process which contributes to β-cell dysfunction and death.  In spite of the importance of islet amyloid formation, the feature that controls the amyloidogenicity and cytotoxicity of amylin has not been understood.  The role of the N-terminus region of amylin in amyloid formation is largely unexplored and no analysis of N-terminal mutants has been reported.  We examined the des-Lys-1 variant of human amylin (h-amylin), the amylin without the first Lys residue. The des-Lys-1 is a variant which is likely produced in vivo. Lys-1 is a region of high charge density in the h-amylin amyloid fiber. The des-Lys-1 polypeptide forms amyloid on the same time scale as wild-type h-amylin in PBS but does so more rapidly in Tris. The des-Lys-1 variant is somewhat less toxic to cultured INS cells than wild type h-amylin.  We also examined K1E and K1I variants of the h-amylin to understand the effect of the N-terminus of the h-amylin on amyloidogenicity and cytotoxicity. The positive charged Lys-1 is replaced by a negative charged Glu in K1E h-amylin and by a neutral amino acid, Ile, in K1I h-amylin. The K1E replacement reduces the net charge by 2 units but amyloid formation in PBS occurs on the time scale similar to that of wild type h-amylin. A Lys-1 to Glu replacement has a weak effect on the amyloid formation but does reduce toxicity relative to that of h-amylin.  The K1I replacement decreases the net charge by 1 unit and the Lys-1 to Ile substitution shows similar tendency of amyloidogenicity and cytotoxicity to the Lys-1 to Glu substitution.  The analysis of the des-Lys-1, K1E and K1I variants of h-amylin provides evidence that the variants have a modest effect on the amyloid formation in PBS but reduces toxicity relative to that of wild type h-amylin.  This analysis also demonstrates that there is not a direct 1:1 direct relationship between the charged residue of the polypeptide and the rate of amyloid formation.  The dependence of the time scale of amyloid formation by wild type h-amylin, des-Lys-1, K1E and K1I h-amylin variants on the choice of buffer highlights the difficulties in objectively defining the amyloidogenicity of a polypeptide because the rate of amyloid formation is dependent upon solution conditions.  The observed buffer-dependent effects reveal the importance of studying amyloid formation under different conditions.

.

 

Biography:

Raluca Komartin is a PhD student at University POLITEHNICA of Bucharest, Faculty of Applied Chemistry and Materials Science, with in-progress thesis entitled "New anticorrosive coatings based on renewable raw materials". The research domain she is working on is the functionalisation of vegetable oils (epoxidation mainly) and the synthesis of composites materials based on renewable raw materials (vegetable oils, lignin etc.), with improved mechanical strength, thermal stability and other properties, for potential application in different industries.

 

Abstract:

The objective of this research is to obtain new composite materials based on epoxidized vegetable oil and lignin derivatives by crosslinking them in varying proportions, under specific reaction conditions, as potential anticorrosion coatings. Highly unsaturated vegetable oils as those extracted from Lallemantia iberica or linseed are important raw materials for various organic compounds via epoxidation. Lallemantia oil (LALO) have several special properties due to its high content of alpha-linolenic acid (a triple unsaturated acid), the iodine number (185 to 205) higher than that of linseed oil (170 to 190). Conversion of the unsaturated vegetable oils in more reactive epoxides, represents an important intermediary step to produce polymeric and composite materials suitable for different applications. Due to the special reactivity of the oxirane rings, epoxidized vegetable oils have a valuable potential for obtaining compounds of various classes (polyols, polyamines), but also for polymeric materials (polymerization or polycondensation products).

The major problem related to the anti-corrosion coatings consists in the low resistance to water vapor diffusion; the water penetrates the interface between the metal and the protective layer, thus reducing the adhesion of the coating. The current research study aims to obtain super-hydrophobic polymeric composites using vegetable oil and lignin derivatives. Beside this, using lignin as filler for epoxidized vegetable oils-derived systems could improve general material performances as mechanical strength and thermal stability. The optimization of the synthesis pathway to produce epoxidized vegetable oil, characterization of the obtained compounds, as well as the materials performances will be presented

Biography:

Oana Maria Ionescu is a PhD student at the dept. of Pharmaceutical Chemistry of the University of Medicine and Pharmacy “Grigore T. Popa” Iasi, Romania, with a bachelor degree in Pharmaceutical Sciences.

 

Abstract:

Wound dressing such as nanofibers are artificial extracellular matrices which show two key properties: a high surface/volume ratio and high porosity responsible for cellular adhesion, proliferation and differentiation. The classical method of producing these biomaterials is via the electrospinning technique, which offers the possibility of working at a nano-scale with a high yield. Blends of natural and synthetic polymers can be a suitable option to overcome low spinnability of natural polymers per se. New nanofibers based chitosan have been developed and characterized. Propolis extract (7.5% v/v), L-arginine HCl (5% wt/v) and Manuka Honey (7.5% wt/v), propolis-Calendula officinalis extract respectively were dissolved in a mixture (1:1 v ratio) of polyehylene-oxide (2% wt/v) and chitosan (3% wt/v) acetic acid solution (50% v/v). The solutions were spun using a 18-gauge-needle at 15-20kV, 20-27 cm needle-collector distance and a 0.2-1 mL/h flow-rate. The viscosity of the solutions was measured using a parallel-plate measuring system. Fiber morphology and average diameters were observed by a scanning electron microscope. By adding the additives to the polymeric solution, both viscosity and fiber diameter increase, which is confirmed by literature data. By increasing of the shear stress, the viscosity decreases. In this work, we successfully developed smooth, continuous Manuka Honey/L-arginine and propolis nanofibers providing a new option for developing wound dressings. 1. Han G. et al., Adv. Ther. 34:599-610, 2017; 2. Kong M. et al. Int. J. Food Microbiol. 144: 51-63, 2010; 3. Yang X. et al., Mater. Des. 119:76–84, 2017; 4. Oryan A, et al., Biomedicine&Pharmacotherapy. 98: 469-483

Biography:

Mr. Muhammad Usman, Former Director General of Agricultural Research System, Government of Pakistan who retired from service after a spotless career of about 32 years with senior level experience on research and development of integrated agricultural production, industries, Agriculture & Horticulture and bioenergy on a sustainable way.

 

Abstract:

The aim of presentation consist of chemistry, health, life, employment, income, economy, global poverty and hunger were studded and concluded Chemistry is the major industry for the development of health, basic need of daily life, create employment, generate income, stronger economy, reducing financial crises, global Poverty and hunger in the developing countries of the world particularly in south Asia. The study reported that Chemistry is the science of the composition, structure, properties and reactions of matter, especially of atomic and molecular systems. In a very simple words, chemistry is the composition, structure, properties and reactions of substance. The different branches of chemistry each of which has the different area including i. Analytical Chemistry uses qualitative and quantitative, observation to identify and measure the physical. ii. Physical chemistry combines chemistry with physics. iii. Organic chemistry specifically studies compounds that contain the element carbon. iv. Inorganic chemistry studies materials such as metals and gases that do not have carbon as part of their makeup. v. Biochemistry is the study of chemical processes that occur within living organisms. vi. Food chemistry deals with the three biological components of food — carbohydrates, lipids and proteins. vii. Environmental chemistry study how chemicals interact with the natural environment. viii. Agricultural chemistry is concerned with the substances and chemical reactions that are involved with the production, protection and use of crops and livestock. Chemical engineering research and develop new materials or processes that involve chemical reactions. Geochemistry combine chemistry and geology to study the makeup and interaction between substances found in the Earth. Nuclear Chemistry is one of a typical classification of chemical science. It primarily utilized for radioactivity which include x-ray, radiotherapy, radioactive components (radon) and so forth. The study reported that the total countries available in the world are 225, consist of (Developed countries = 49, developing countries = 150, observer state = 4, state without partial recognition = 8, unrecognized state = 14). Similarly, South Asia comprises the countries of Pakistan, Bangladesh, India, Bhutan, Maldives, Nepal and Sri Lanka.  In the light of above study, it is proposed that Chemistry should be commercialized  for the development of health, basic need of daily life, create employment, generate income, stronger economy, reducing financial crises, global Poverty and hunger in the developing countries of the world particularly in south Asia

 

 

Biography:

Samantha studying the last semester of Chemical Engineering at the National Polytechnic School in Quito, Ecuador. She has specialized in the mention of Food Technology and Environmental Remediation. Currently, she is part of a research project to obtain Adhesives from Polyvinyl Alcohol (PVA)

 

Abstract:

The development of adhesives from renewable raw materials attract the attention of the scientific community, due to it promises the reduction of the dependence with materials derived from oil. This work proposes the use of modified “oca (oxalis tuberose)” starch and polyvinyl alcohol (PVA) in the elaboration of adhesives for lignocellulose substrates. The investigation focused on the formulation of adhesives with 3 different PVA:starch (modified and native) ratios (of 1:0,33; 1:1; 1:1,67 ). The first step to perform it was the chemical modification of starch through acid hydrolysis and a subsequent urea treatment to get carbonate starch. Then, the adhesive obtained was characterized in terms of instantaneous viscosity, Fourier-transform infrared spectroscopy (FTIR) and shear strength. The results showed that viscosity and mechanical tests exhibit data with the same tendency in relation to the native and modified starch concentration. Itwas observed that the data started to reduce its values to a certain concentration, where the values began to grow. On the other hand, 2 relevant bands were found in the FTIR spectrogram. The firstin 3300 cm-1of OH group with the same intensity for all the essays and the other one in 2900 cm-1belonging to the group of alkanes with a different intensity for each adhesive. On the whole, theratio PVA:starch (1:1) will not favor crosslinking in the adhesive structure and causes the viscosity reduction whereas in the others ones the viscosity is higher. It was also observed that adhesives made with modified starch had better characteristic, but the adhesives with high concentrations of native starch could equals the properties of the adhesives made with low.